David Sadava
Pritzker Family Foundation Professor of Biology
Professor of Biology
Email: dsadava@kecksci.claremont.edu
Office Hours: Emeritus
Web Site:
Educational Background:
B.S., Carleton University, Ottawa
Ph.D., University of California, San Diego
Research Interests:
Cancer chemotherapy using conventional and less conventional approaches
Drug resistance in tumor cells
Selected Publications List: Click to open new window.
1.   Sadava, D., Heller, C., Orians, G., Purves, W. and Hillis, D. . (2008). .  Sinauer Associates and WH Freeman and Co. : . Article
2.   D. Sadava, E. Whitlock, S. E. Kane . (2007). The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells. Biochemical and Biophysical Research Communications   360: 233-237.
3.   D. Sadava and W, Hamman . (2007). RNA interference against MDR1 but not MRP1 reverses drug resistance in human small-cell lung cancer cells. Journal of Cancer Molecules   3: 91-94.
4.   D Sadava . (2006). "The story of PC-SPES and prostate cancer". Textbook of Complementary and Alternative Medicine C. Yuan Taylor and Francis Medical Books : .
5.   D Sadava and J Winesburg . (2005). Contaminants are not responsible for cytotoxicity of PC-SPES in human small-cell lung carcinoma cells”. Cancer letters   220: 171-175.
6.   W. Purves, G. Orians, C. Heller, D. Sadava . (2004). Life: The Science of Biology.  Sinauer Associates- WH Freeman 6: .
7.   M. Chrispeels and D, Sadava . (2003). Plants, Genes and Crop Biotechnology.  ASPB./Jones and Bartlett : .
8.   R. E. Schwarz, C. Donohue, S. Kane, D. Sadava . (2003). Pancreatic cancer toxicity mediated by Chinese herbs SPES and PC-SPES: Implications for monotherapy and combination treatment. Cancer Letters   189: 59-68. Abstract Article
9.   J. Ahn, M. Zhan, M. Pang, J. Ding, S. Kane, D. Sadava . (2002). Effects of four Chinese herbal extracts on drug-sensitive and drug-resistant human small-cell lung carcinoma cells. Cancer Chemotherapy Pharmacol   49: 261-266.
10.   C. Lin, T. Phillips, S. Kane, D. Sadava . (2002). Artemisinin and transferrin: Use in overcoming drug resistance in small cell lung cancer cells. Cancer Letters   172: 151-156.
11.   A. Coleman, S. Kane . (2002). Liposomal daunorubicin overcomes multi-drug resistance in human breast cancer, ovarian cancer and small cell lung cancer cells. J. Lipos. Res.   12: 301-309.
12.   W. Purves, G. Orians, C. Heller, D. Sadava . (2001). Life: The Science of Biology.  Sinauer Associates. W. H. Freeman 6: .
13.   W. Purves, G. Orians, C. Heller, D. Sadava . (2001). Life: The Science of Biology.  Sinauer Associates - W. H. Freeman 5: .
14.   K. Heidel, A. McMurtray, K. Scanlon, D. Sadava . (1998). Neuron-specific enolase and thymidine kinase: Markers for multi-drug resistance and its reversal in human small-cell lung cancer cells. J. Tumor Marker Oncol.   13: 49-52.
15.   T. Remer, K. Peterson, D. Sadava . (1997). Hyperplasia, hyperproliferation and decreased migration rate of colonic epithelial cells in mice fed a diet deficient in vitamin D. Bio. Cell   87: 113-116. Abstract Article
16.   D. Alonso, H. Hong, D. Pettit-Barrett, D. Sadava . (1997). Effect of methadone addiction on glucose metabolism in rats. Gen. Pharmacol   28: 27-29. Abstract
17.   A. McMurtray, K. Heidel, D. Sadava . (1997). Markers for multi-drug resistance and its reversal in human small-cell lung cancer cells. J. Tumor Marker Oncol.   87: 113-116.
18.   T. Castillo, D. Sadava . (1996). Growth of human small-cell lung cancer cells in AIM-V, a serum-free medium. Focus   18: 59-60.
19.   P.W. Luo, J. Casper, D. Sadava . (1996). Induction of renal damage to rats by a diet deficient in antioxidents. Nutr. Res.   16: 1607-1612.
20.   H. Kijima, H. Ishida, L. Xia, K. J. Scanlon, D. Sadava . (1995). The role of oncogenes in drug-resistant human carcinoma cells. AACR Proceedings   36: 343.
21.   M. Chrispeels, D. Sadava . (1994). Plants, Genes and Agriculture.  Jones and Bartlett, Publishers : .
22.   J. Tsai, S. Gould, D. Sadava . (1994). Imaging of the P-glycoprotein in normal and MDR small cell lung carcinoma cells with the atomic force microscope. Proc. Mtg. Microscopy Society (G. Bailey and A. Garrett-Reid, eds.)  : 1074-5.
23.   D. Sadava . (1993). Cell Biology: Organelle Structure and Function.  Jones and Bartlett Publishers : .
24.   P. Frykman, E. Harris, D. Majerus, J. Mustard, B. Bernard, D. Sadava . (1992). Development of enzymes of glycolysis and gluconeogenesis in human fetal liver. Biol. Neonate   62: 89-95.
25.   B. Bernard, D. Sadava . (1990). Transition from cytosolic to mitochondrial thymidine kinase during development in human fetal tissues. Life Sci.   47: 2359-2394.
26.   D. Sutcliffe, D. Sadava . (1988). The effects of maternal hyperphenylalaninemia on learning in mature rats. Life Sci.   43: 1119-1123.
27.   K. Moore, D. Sadava . (1987). Glycerol metabolism in higher plants: glycerol kinase. Biochem. Biophys. Res. Commun   143: 977-983.
28.   M. Depper, M. Gilbert, B. Bernard, E. McCabe, D. Sadava . (1987). Development of enzymes of glycerol metabolism in human fetal liver. Biol Neonate   52: 26-33.
29.   D. Sadava . (1987). Increased cellular turnover rate of colonic but not duodenal epithelium in mice fed a high fiber diet. Med. Sci. Res.   15: 583-584.
30.   B. Mack, D. Sadava . (1986). Effect of methadone addiction on cyclic nucleotide levels in regions of rat brain. Life Science   39: 477-481.
31.   K. Wilmington, D. Sadava . (1984). Tricyclic antidepressant drugs affect histamine receptors in human leukocytes.. Life Science   35: 2545-2548.
32.   H. McKelvey, E. McCabe, C. Rose, D. Sadava . (1982). Glycerol kinase deficiency: enzyme kinetics and fibroblast hybridization. J. Inherit. Metab. Dis.   5: 177-182.
33.   D. Watumull, K. Sanders, K. Downey, D. Sadava . (1982). The affect of vitamin C on the rapid induction of aortic changes in rabbits.. J. Nutr. Sci.   28: 85-92.
34.   E. McCabe, W. Seltzer, R. Hill, D. Sadava . (1982). Glycerol kinase: developmental biochemistry in man. Pediatric Research   16: 298.
35.   B. Bernard, K. Elliott, D. Sadava . (1980). Multiple forms of thymidine kinase in serum of premature infants. Biol. Neonate.   38: 287-290.
36.   . (1978). Synthesis and secretion of cell wall glycoproteins in carrot root disks. Biochemistry of Wounded Plant Tissues (G. Kahl, W. de Gruyter ed.)  : 85-102.
37.   M. Chrispeels, D. Sadava . (1978). Extensin: role in the cessation of elongation in excised pea epicotyls. Develop. Biol.   30: 49-57.
38.   M. Chrispeels, D. Sadava . (1977). Plants, Food and People.  W.H. Freeman and Co. : .
39.   T. Field, A. McNelly, D. Sadava . (1977). Effect of maternal methadone addiction on offspring in rats. Arch. Int. Pharm. Ther.   228: 300-305.
40.   B. Bernard, P. Beaupre, K. Elliott, B. Preston, D. Sadava . (1977). Multiple forms of thymidine kinase during human development. Biol. Neonate.   228: 300-305.
41.   B. Bernard, P. Beaupre, K. Elliott, B. Preston, D. Sadava . (1977). Multiple forms of thymidine kinase during human development. Biol. Neonate.   31: 225-228.
42.   B. Volcani, D. Sadava . (1977). Biochemistry of silica shell formation in diatoms. Planta   135: 7-11.
43.   M. Schoenfield, D. Sadava . (1976). Effect of methadone addiction on N demethylation activity of rat liver microsomes. Arch. Int. Pharm. Ther.   219: 347-350.
44.   D. Sadava . (1976). Attitudes toward science of nonscience major undergraduates . J. Res. Sci. Tchg   13: 69-84.
45.   M. Sloane, D. Sadava . (1975). Auxin, carbon dioxide and hydrogen ions. Nature   257: 68.
46.   Y. Cho, M. Chrispeels, D. Sadava . (1974). Enhancement of extensin biosynthesis in aging disks of carrot storage tissue.. J. Exp. Botany   25: 1157 1166.
47.   M. Flaherty, D. Sadava . (1974). A rat model for methadone addiction. Arch. Int. Pharm. Ther.   212: 103-108.
48.   S. Ferronato, D. Thomas, D. Sadava . (1974). Preferences for handedness, arm folding, and hand clasping in families. Human Heredity   24: 345-352.
49.   D. Sadava, M. Chrispeels . (1974). Synthesis and secretion of proteins in plant cells. Macromolecules Regulating Growth and Development (E. Hay ed.) Academic Press : 131-152.
50.   D. Sadava . (1973). Biogenesis of cell wall protein. Biogenesis of Plant Cell Wall Polysaccharides (F. Loewus ed.) Academic Press : 165-175.
51.   F. Walker, M. Chrispeels, D. Sadava . (1973). Extensin: synthesis and accumulation in growing pea epicotyls.. Develop. Biol.   30: 42-48.
52.   M. Chrispeels, D. Sadava . (1971). Peptidyl proline hydroxylase in carrot disks. Biochem. Biophys. Acta   227: 278-287.
53.   D. Sadava, M. Chrispeels . (1971). Intracellular site of proline hydroxylation in plant cells. Biochemistry   10: 4290-4295.
54.   M. Chrispeels, D. Sadava . (1969). Cell wall protein in plants: autoradiographic evidence. Science   165: 299-300.
55.   D. Sadava, C. Miller . (1967). Taxonomy of last instar larval remains of Spilonota ocellana. Canad. Ent.   99: 436-442.