Jennifer A Armstrong
Associate Dean of Faculty, Scripps College
Professor of Biology
Office: Balch 134
Phone: 909-607-9716
Office Hours: Mondays and Thursdays 8:30-9:30 and by appointment
Web Site:
Educational Background:
postdoc: University of California, Santa Cruz
PhD: University of California, San Diego
BS: New Mexico State University
Courses Taught:
Genetics, Cell Biology, Introductory Biology (BIOL43L), Molecular Biology Seminar/Laboratory, Epigenetics, Scripps Core I: Histories of the Present: Human Nature and Human Difference, Core II: Constructions of (Dis)Ability
Research Interests:
chromatin and chromosome structure and gene regulation
Thesis Topics:
My laboratory focuses on chromatin remodeling factors, which utilize the energy of ATP to slide, remodel, or assemble nucleosomes. Understanding the normal function of these proteins is critical since their loss can lead to mis-regulation of the genome and several distinct forms of disease, including cancer.
Selected Publications List: Click to open new window.
1.   Kim S, Bugga L, Hong ES, Zabinsky R, Edwards RG, Deodhar PA, Armstrong JA . (2015). An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster. G3   6: 245-54. Abstract Article
2.   Bugga L, McDaniel IE, Engie L, Armstrong JA . (2013). The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2. PLoS One   8: e59496. Abstract Article
3.   Marta Radman-Livaja, Tiffani K. Quan, Lourdes Valenzuela, Jennifer A. Armstrong, Tibor van Welsem, TaeSoo Kim, Laura J. Lee, Stephen Buratowski, Fred van Leeuwen, Oliver J. Rando, Grant A. Hartzog . (2012). A Key Role for Chd1 in Histone H3 Dynamics at the 3′ Ends of Long Genes in Yeast. PLoS Genetics   : 10.1371/journal.pgen.1002811. Abstract Article
4.   McDaniel IE, Lee JM, Berger MS, Hanagami CK, Armstrong JA . (2008). Investigations of CHD1 function in transcription and development of Drosophila melanogaster. Genetics   1: 583-587. Abstract Article
5.   Burgio G, La Rocca G, Sala A, Arancio W, Di Ges D, Collesano M, Sperling AS, Armstrong JA, van Heeringen SJ, Logie C, Tamkun JW, Corona DF . (2008). Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI.. PLoS Genetics   4: e1000089. Abstract Article
6.   Armstrong JA . (2007). Negotiating the nucleosome: factors that allow RNA polymerase II to elongate through chromatin. Biochemistry and Cell Biology   85: 426-434. Abstract Article
7.   Armstrong, JA and Schulz, JS . (2007). Agarose Gel Electrophoresis. Current Protocols in Essential Laboratory Techniques  Wiley Publishers : .
8.   Corona DF, Siriaco G, Armstrong JA, Snarskaya N, McClymont SA, Scott MP, Tamkun JW . (2007). ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biology   5: e232. Abstract Article
9.   Srinivasan S, Armstrong JA, Deuring R, Dahlsveen IK, McNeill H, Tamkun JW . (2005). The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II. Development   132: 1623-1635. Abstract Article
10.   Armstrong JA, Sperling AS, Deuring R, Manning L, Moseley SL, Papoulas O, Piatek CI, Doe CQ, Tamkun JW . (2005). Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila. Genetics   170: 1761-1774. Abstract Article
11.   Corona D.F., Armstrong, J.A., and Tamkun, J.W . (2004). Genetic and Cytological Analysis of Drosophila Chromatin-Remodeling Factors. Methods in Enzymology   377: 70-85.
12.   Armstrong, J.A., Papoulas, O., Daubresse, G., Sperling, A.S., Lis, J.T., Scott, M.P., and Tamkun, J.W . (2002). The Drosophila BRM Complex Facilitates Global Transcription by RNA Polymerase II. EMBO Journal   21: 5245-5254. Abstract
13.   Moshkin, Y.M., Armstrong, J.A., Maeda, R.K., Tamkun, J.W., Verrijzer, P., Kennison, J.A., and Karch, F . (2002). Histone Chaperone ASF1 Cooperates with the Brahma Chromatin Remodeling Machinery. Genes and Development   16: 2621-2626. Article
14.   Mollaaghababa, R., Sipos, L., Tiong, S.Y.K., Papoulas, O., Armstrong, J.A., Tamkun, J. W., and Bender, W . (2001). Mutations in Drosophila heat shock cognate 4 are Enhancers of Polycomb. Proc. Natl. Acad. Sci.   98: 3958-3963. Article
15.   Papoulas, O., Daubresse, G., Armstrong, J.A., Jin, J., Scott, M.P., and Tamkun, J.W . (2001). The HMG-Domain Protein BAP111 Is Important for the Function of the BRM Chromatin-Remodeling Complex In Vivo. Proc. Natl. Acad. Sci.   98: 5728-5733. Article
16.   Deuring, R., Fanti, L., Armstrong, J.A., Sarte, M., Papoulas, O., Prestel, M., Daubresse, G., Verardo, M., Moseley, S.L., Berloco, M., Tsukiyama, T., Wu, C., Pimpinelli, S., and Tamkun, J.W . (2000). The ISWI Chromatin-Remodeling Protein Is Required for Gene Expression and the Maintenance of Higher Order Chromatin Structure In Vivo. Molecular Cell   5: 355-365. Abstract Article
17.   Armstrong, J.A., Bieker, J.J., and Emerson, B.M . (1998). A SWI/SNF-Related Chromatin Remodeling Complex, E-RC1, Is Required for Tissue-Specific Transcriptional Regulation by EKLF In Vitro. Cell   95: 93-104. Abstract Article
18.   Bagga, R., Armstrong, J.A., and Emerson, B.M . (1998). The Role of Chromatin Structure and Distal Enhancers in Tissue-Specific Transcriptional Regulation In Vitro. Cold Spring Harbor Symposia on Quantitative Biology   63: 569-576.
19.   Armstrong, J.A. and Emerson, B.M . (1998). Transcription of Chromatin: These are Complex Times. Current Opinion in Genetics and Development   8: 165-172. Abstract
20.   Armstrong, J.A. and Emerson, B.M . (1996). NF-E2 Disrupts Chromatin Structure at Human β-Globin Locus Control Region Hypersensitive Site 2 In Vitro. Molecular and Cellular Biology   16: 5634-5644. Abstract Article
21.   Oliver, M.J., Armstrong, J., and Bewley, J.D . (1993). Desiccation and the Control of Expression of β-Phaseolin in Transgenic Tobacco Seeds. Journal of Experimental Botany   44: 1239-1244. Article