Research Publication
Assoc Bio Prof Jennifer Armstrong & research lab
Research Associate Lakshmi Bugga; Associate Professor of Biology Jennifer Armstrong; Ivy McDaniel, SCR '08; and Liana Engie, PZ '11; have published a research article in the journal PLOS ONE. The article, "The Drosophila melanogaster CHD1 Chromatin Remodeling Factor Modulates Global Chromosome Structure and Counteracts HP1a and H3K9me2," presents results from a study of DNA and proteins in the fruitfly.

According to Professor Armstrong: In our cells DNA is packaged with proteins to form a structure called chromatin, and the regulation of chromatin structure is critical for gene expression and development. The evolutionarily conserved protein CHD1 is a chromatin-remodeling factor that is required for maintaining the pluripotency of embryonic stem cells in mice, and the CHD1 gene is a common deletion in prostate tumor cells in humans. It is therefore of high interest to understand how the CHD1 protein functions in our cells. Using the fruit fly as a model organism, we have found that CHD1 modulates the presence of key chromatin-associated proteins that determine the extent of DNA packaging, and that CHD1 is important for global chromosome structure.


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