Research Publication
Assoc. Professor of Biology Zhaohua Irene Tang
The team studies enzymes known as LAMMER kinases, which play vital roles in cell growth/differentiation, development, and metabolism. These kinases are conserved through evolution from yeasts to humans. Kic1 is the LAMMER kinase member in fission yeast Schizosaccharomyces pombe. One of the best known functions of the kinases in animal cells is the regulation of pre-mRNA splicing. However, it remains elusive whether this function of the kinase family is conserved in unicellular eukaryotes. In this study, we demonstrate for the first time that Kic1 functions in multiple steps of pre-mRNA processing, including splicing and mRNA export. The novel information about the in vivo functions, cellular localization, and regulation of Kic1 during the cell cycle provides insights into the conserved biological roles fundamental to LAMMER kinases in eukaryotes. See the reference Experimental Cell Research, doi:10.1016/j.yexcr.2011.06.014  


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