Research Publication
Assoc. Professor of Chemistry Anna Wenzel
Efficient methods for the preparation of 1,1’-bi-2-aryl diols are highly sought after, as these compounds are ubiquitous to many areas of catalysis, materials chemistry, and medicinal chemistry, among others. For example, 1,1’-bi-2-aryl diols can serve to protect plastics against the degradative action of ultraviolet light or as novel materials for liquid crystal displays. Biaryl diols have also seen recent use in the treatment of neurodegenerative diseases.

In a recent issue of the Journal Synthetic Communications, Sharday Grant-Overton (CMC ’11), Joshua Allen Buss (CMC ’12), Eva H. Smith (Scripps ‘09), Elisa G. Gutierrez (CMC ‘09), Eric J. Moorhead (CMC ’08), and Vivian S. Lin (CMC ’09) of the Wenzel group reported an optimized protocol for the preparation of 1,1’-bi-2-aryl diols. This protocol enables higher yields (up to 98%), shorter reaction times (10 min), greater reactant concentrations, and the use of less reagent relative to comparable methods.

Reference: Grant-Overton, S.; Buss, J. A.; Gutierrez, E. G.; Eric J. Moorhead, E. J.; Wenzel, A. G. Synthetic Communications 2015, 45, 331-337.



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