Amy R. Babbes
Visiting Assistant Professor of Chemistry
 
Email: ababbes@kecksci.claremont.edu
Office: Keck Science Center 118
Phone: 909-607-8272
Office Hours: Mon 2-4 pm, Tues 9-11 am, Thurs 1:15-2:15 pm
Web Site:
   
Educational Background:
B.S. Biological Sciences (Biochemistry), Michigan Technological University
Ph.D. Medicinal Chemistry, University of Michigan
NIH Postdoctoral Fellow, The Scripps Research Institute
Courses Taught:
General Chemistry, Biochemistry, Advanced Lab
Research Interests:
Enzyme reaction mechanisms, characterization of novel bacterial proteins, biological oxidation–reduction reactions
 
Selected Publications List: Click to open new window.
1.   A. R. Hurshman Babbes, E. T. Powers, and J. W. Kelly . (2008). Quantification of the Thermodynamically Linked Quaternary and Tertiary Structural Stabilities of Transthyretin and Its Disease-Associated Variants: The Relationship between Stability and Amyloidosis. Biochemistry   47: 6969-6984. Abstract Article
 
2.   A. R. Hurshman, J. T. White, E. T. Powers, and J. W. Kelly . (2004). Transthyretin Aggregation Under Partially Denaturing Conditions Is a Downhill Polymerization. Biochemistry   43: 7365-7381. Abstract Article
 
3.   A. R. Hurshman, C. Krebs, D. E. Edmondson, and M. A. Marletta . (2003). Ability of Tetrahydrobiopterin Analogues to Support Catalysis by Inducible Nitric Oxide Synthase: Formation of a Pterin Radical Is Required for Enzyme Activity. Biochemistry   42: 13287-13303. Abstract Article
 
4.   A. R. Hurshman and M. A. Marletta . (2002). Reactions Catalyzed by the Heme Domain of Inducible Nitric Oxide Synthase: Evidence for the Involvement of Tetrahydrobiopterin in Electron Transfer. Biochemistry   41: 3439-3456. Abstract Article
 
5.   P. Hammarstrom, X. Jiang, A. R. Hurshman, E. T. Powers, and J. W. Kelly . (2002). Sequence-Dependent Denaturation Energetics: A Major Determinant in Amyloid Disease Diversity. Proc. Natl. Acad. Sci. U.S.A.   99: 16427-16432. Abstract Article
 
6.   A. R. Hurshman, C. Krebs, D. E. Edmondson, B. H. Huynh, and M. A. Marletta . (2000). Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen. Biochemistry   38: 15689-15696. Abstract Article
 
7.   M. A. Marletta, A. R. Hurshman, and K. M. Rusche . (1998). Catalysis by Nitric Oxide Synthase. Curr. Opin. Chem. Biol.   2: 656-663. Abstract Article
 
8.   A. R. Hurshman and M. A. Marletta . (1995). Nitric Oxide Complexes of Inducible Nitric Oxide Synthase: Spectral Characterization and Effect on Catalytic Activity. Biochemistry   34: 5627-5634. Abstract Article