CHEM14L: Basic Principles of Chemistry (Lab only; F12, F13) CHEM29L: Accelerated General Chemistry (Lecture only; F14) CHEM40L: Introduction to Biological Chemistry (F15, F16, F17) CHEM125L: Advanced Laboratory in Biochemistry (S20) CHEM127L: Advanced Laboratory II (S13, S14, S15, S17) BIO/CHEM177: Biochemistry (F12, F13, F14, S15, S18, F19) CHEM180: Applied Biomolecular Evolution (S14, S18, S20) CHEM199: Independent Study (S14, S15, S16, S18)
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1.
A. S. Thompson, S. E. Barrett, A. G. Weiden, A. Venkatesh, M. K. C. Seto, S. Z. P. Gottlieb, and A. M. Leconte
. (2020). Accurate and efficient one-pot reverse transcription and amplification of 2’ fluoro-modified nucleic acids by commercial DNA polymerases. Biochemistry
: .
Abstract
Article
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2.
M. D. Liu*, E. A. Warner*, C. A. Morrissey, C. W. Fick, T. S. Wu, M. Y. Ornelas, G. V. Ochoa, B. Zhang, C. M. Rathbun, W. B. Porterfield, J. A. Prescher, and A. M. Leconte
. (2018). Statistical Coupling Analysis-guided library design for discovery of mutant luciferases. Biochemistry
57: 663.
Abstract
Article
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3.
S. L. Rosenblum, A. G. Weiden, E. L. Lewis, A. L. Ogonowsky, H. E. Chia, S. E. Barrett, M. D. Liu, and A. M. Leconte
. (2017). Design and discovery of new combinations of mutant DNA polymerases and modified DNA substrates. Chembiochem
18: 816.
Abstract
Article
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4.
E. L. Lewis and A. M. Leconte
. (2017). DNA polymerase activity assay using near-infrared fluorscent labeled DNA visualized by acrylamide gel electrophoresis. Journal of Visualized Experiments
128: e56228.
Abstract
Article
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5.
H.J. Schultz, A. M. Gochi, H. E. Chia, A. L. Ogonowsky, S. Chiang, N. Filipovic, A. G. Weiden, E. E. Hadley, S. E. Gabriel and A. M. Leconte
. (2015). Taq DNA polymerase mutants and 2’ modified sugar recognition. Biochemistry
54: 5999.
Abstract
Article
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6.
A. M. Leconte, B. C. Dickinson, D. D. Yang, I. A. Chen, B. Allen, D. R. Liu
. (2013). A Population-Based Experimental Model for Protein Evolution: Effects of Mutation Rate and Selection Stringency on Evolutionary Outcomes. Biochemistry
52: 1490.
Abstract
Article
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7.
B. C. Dickinson , A. M. Leconte, B. Allen, K. M. Esvelt, and D. R. Liu
. (2013). Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proc. Natl. Acad. Sci.
110: 9007.
Abstract
Article
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8.
M. H. Duyzend, C. T. Clark, S. L. Simmons, W. B. Johnson, A. M. Larson, A. M. Leconte, A. W. Willis, M. Ginder-Vogel, A. K. Wilhelm, J. A. Czechowicz, and D. G. Alberg
. (2012). Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase. J. Enzyme Inhib. Med. Chem.
27: 784.
Abstract
Article
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9.
C. E. Dumelin, Y. Chen; A. M. Leconte, Y. G. Chen, D. R. Liu
. (2012). Discovery and Biological Characterization of Geranylated RNA in Bacteria. Nature Chemical Biology
8: 913.
Abstract
Article
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10.
A. M. Leconte, M. P. Patel, L. E. Sass, P. McInerney, M. Jarosz, L. Kung, J. L. Bowers, P. R. Buzby, J. W. Efcavitch, and F. E. Romesberg
. (2010). Directed evolution of DNA polymerases for next generation sequencing. Angew. Chem. Int. Ed.
34: 5921.
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11.
A. M. Leconte and F. E. Romesberg
. (2009). Development of Unnatural DNA Base Pair Systems. (invited book chapter) Protein Engineering
Springer : .
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12.
Y. Hari, G. T. Hwang, A. M. Leconte, N. Joubert, M. Hocek and F. E. Romesberg
. (2008). Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication. Chembiochem
9: 2796.
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13.
A. M. Leconte, G. T. Hwang, S. Matsuda, P. Capek, Y. Hari, and F. E. Romesberg
. (2008). Discovery, Characterization, and Optimization of an Unnatural Base Pair for Expansion of the Genetic Alphabet. J. Am. Chem. Soc.
130: 2336.
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14.
G. T. Hwang, A. M. Leconte, and F. E. Romesberg
. (2007). Polymerase Recognition and Stability of Fluoro-Substituted Pyridone Nucleobase Analogues. Chembiochem
8: 1606.
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15.
S. Matsuda, A. M. Leconte, and F. E. Romesberg
. (2007). Minor Groove Hydrogen Bonds and the Replication of Unnatural Base Pairs. J. Am. Chem. Soc.
129: 5551.
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16.
A. M. Leconte and F. E. Romesberg
. (2006). Chemical biology: a broader take on DNA. (invited commentary) Nature
444: 553.
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17.
A. M. Leconte and F. E. Romesberg
. (2006). Amplify this! DNA and RNA get a third base pair. (invited commentary) Nature Methods
3: 667.
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18.
A. M. Leconte, S. Matsuda, G. Hwang, and F. E. Romesberg
. (2006). Efforts toward Expansion of the Genetic Alphabet: Methyl Pyridone and Pyridone Nucleobases. Angew. Chem. Int. Ed.
45: 4326.
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19.
Y. Kim, A. M. Leconte, Y. Hari, and F. E. Romesberg
. (2006). Stability and Polymerase Recognition of Pyridine Nucleobase Analogs. Angew. Chem. Int. Ed.
45: 7809.
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20.
A. M. Leconte, S. Matsuda, and F. E. Romesberg
. (2006). An Efficiently Extended Class of Unnatural Base Pairs. J. Am. Chem. Soc.
128: 6780.
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21.
A. M. Leconte, L. Chen, and F. E. Romesberg
. (2005). Polymerase Evolution: Efforts toward Expansion of the Genetic Code. J. Am. Chem. Soc.
127: 12470.
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