Keck Science :: Faculty and Staff : Faculty Profile

Zhaohua Irene Tang

Professor of Biology

Email:

ztang@kecksci.claremont.edu

Office:

Keck Science Center 201

Phone:

909-607-9067

Office Hours:

Monday and Wednesday 2:00-3:30 PM

Web Site:

Educational Background:

Peking University Medical School, Beijing, P. R. of China
B.S. State University of New York at Stony Brook
Ph.D. University of California, Los Angeles
Postdoctoral Fellow, California Institute of Technology, Pasadena, CA

Courses Taught:

Regulation of the Cell-division Cycle (lecture)
Physical Chemistry for Molecular Biology Program (lecture)

Introductory Biology, lecture and lab (Molecular, Cell Biology and Genetics)
Cell Biology, lecture and lab
Cell Cycle, Diseases, and Aging (lecture)
Biology 177 Biochemistry (Lecture)
AISS (Accelerated Interdisciplinary Science Series)
Bio 43 Introductory Biology Lecture and Lab

Research Interests:

To investigate the functions of several protein kinases in the regulation of cell cycle progression and cell death, in the response to environmental factors, as well as in the cellular sensitivity to anticancer drugs, using a single-cell eukaryotic organism, fission yeast Schizosaccharomyces pombe as an in vivo model.
External Research Fund obtained:
NSF grant for Research in Undergraduate Institution (RUI)
NIH R15 Grant

Thesis Topics:

1. Cell signaling for the interplay between cell-division cycle and gene expression events such as pre-mRNA processing, mRNA export, as well as heterochromatic silencing in eukaryotes involving several protein kinases including Dsk1 and Kic1. 2. Genomic studies on genes involved in the cellular sensitivity and resistance to platinum-based anticancer drugs 3. Genomic studies on conserved response networks to phenol derivatives as environmental stress factors

Selected Publications List: Click to open new window.

1. Mei Wu, Gang Feng, Buyu Zhang, Kaikun Xu, Zhen Wang, Sen Cheng, Cheng Chang, Aditi Vyas, Zhaohua Tang, and Xiaoyun Liu . (2020). Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase. Journal of Proteome Research, accepted February 16, 2020 Accepted by Journal of Proteome Research/ACS Publications, 16 Feb 2020 : . Abstract Article

2. 20 student authors (Alhoch et al.), 6 faculty authors ( K. Purvis-Roberts, C. Selassie, G. Edwalds-Gilbert, M. C. Negritto, R. Wang and Z. Tang) . (2019). Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress. G3 Genes Genomes Genetics American Society of Genetics 9: 639-650. Abstract Article

3. Zhaohua Tang and Gretchen Edwalds-Gilbert . (2016). Nucleic Acid and Protein Sample Preparation from Yeasts (Chapter 20). Peer-reviewed Book, Sample Preparation Techniques for Soil, Plant, and Animal Samples, Springer Protocols Handbooks M. Micic (ed.), Springer, New York DOI 10.1007/978-1-4939-3185-9_20 © Springer: .

4. Zhaohua Tang . (2015). Model Organisms for Studying the Cell Cycle (Chapter 2) . Peer-reviewed Book, Cell Cycle Oscillators: Methods and Protocols, Methods in Molecular Biology Amanda S. Coutts and Louise Weston (eds.), Springer, New York 1342: 21-57.

5. Zhaohua Tang, Maria Luca, Laura Taggart-Murphy, Jessica Portillio, Cathey Chang, Ayse Guven, Ren-Jang Lin, Johanne Murray, and Antony Carr . (2012). Interacting Factors and Cellular Localization of SR Protein-specific Kinase Dsk1.. Experimental Cell Research 318 (16): 2071-2084. Abstract Article

6. Zhaohua Tang, Maria Luca, Jessica Portillio, Benson Ngo, Cathey Chang, Teresa Wen, Johanne Murray, and Antony Carr . (2011). LAMMER Kinase Kic1 Is Involved in Pre-mRNA Processing. . Experimental Cell Research 317: 2308-2320. Abstract Article

7. Zhaohua Tang . (2010). The Domino and Clock Models of Cell Cycle Regulation. Nature Education 3(9): 56. Article

8. Nicole M. Duggan* and Zhaohua Tang . (2010). The Formation of Heterochromatin and RNA interference. Nature Education 3(9): 5. Article

9. Tang, Z., Alaei, Tsurumi, A., C., Wilson, C., S., Chiu, C., Oya, J., and Ngo, B. . (2007). Dsk1 Kinase Phosphorylates SR Proteins and Regulates Their Cellular Localization in Fission Yeast. . Biochemical Journal 405 (1): 21-30. Abstract Article

10. Huang, C-J, Tang, Z, Lin, R.-J, and Tucker, P.W. . (2007). Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract. . FEBS lett 581(2): 223-232. Abstract

11. Tang, Z., Mandel, L., Yean, S.-L., Lin*, C.X., Chen*, T., Yanagida, M., and Lin, R.-J. . (2003). The Kic1 Kinase of Schizosaccharomyces pombe Is a CLK/STY Orthologue That Regulates Cell-Cell Separation. Experimental Cell Research 283: 101-115. Abstract Article

12. Portal, D., Lobe, G.S., Kadener, S., Prasad, J., Espinosa, J.M., Pereira, C.A., Tang, Z., Lin, R.-J., Manley, J.L., Kornblihtt, A.R., Flawia M.M., and Torres H.N. . (2003). Trypanosoma cruzi TcSRPK, The First Protozoan Member of The SRPK Family, Is Biochemically and Functionally Conserved with Metazoan SR Protein-specific Kinases. Molecular and Biochemical Parasitology 127: 9-21. Abstract Article

13. Portal, D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., De La Mata M., Tang Z., Lin R.-J., Kornblihtt A.R., Baralle F.E., Flawia M.M., and Torres H.N. . (2003). An Early Ancestor in The Evolution of Splicing: A Trypanosoma Cruzi Serine-arginine-rich Protein (TcSR) Is Functional in Cis-splicing. Molecular and Biochemical Parasitology 127: 37-46. Abstract Article

14. Tang, Z., Käufer, N. F., and Lin, R.-J. . (2002). Interactions Between Two Fission Yeast SR-Related Proteins and Their Modulation by Phosphorylation. Biochemical Journal 368: 527-534. Abstract

15. Tang, Z., Kuo*, T., Shen*, J., and Lin, R.-J. . (2000). Biochemical and Genetic Conservation of Fission Yeast Dsk1 and Human SRPK1.. Mol. Cell. Biol 20(3): 816-824. Abstract Article

16. Tang, Z., Yanagida, M., and Lin, R.-J. . (1998). Fission Yeast Mitotic Regulator Dsk1 Is an SR Protein-Specific Kinase.. J. Biol. Chem 273: 5963-5969. Abstract Article

17. Coleman, T.R., Tang, Z., and Dunphy, W.G. . (1993). Negative Regulation of the Weel Protein Kinase by Direct Action of the Nim1/Cdr1 Mitotic Inducer. Cell 72: 919-929.

18. Tang, Z., Coleman, T.R., and Dunphy, W.G. . (1993). Two Distinct Mechanisms for Negative Regulation of the Wee1 Protein Kinase.. EMBO 12(9): 3427-3436. Abstract