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Katherine N. Liu, Chen-min S. Hung, Michael A. Swift, Kristen A. Muñoz, Jose L. Cortez and Babak Sanii*. 2015. Configurable lipid membrane gradients quantify diffusion, phase separations and binding densities. Soft Matter 11: 8217-8220. Full Article

Single-experiment analysis of phospholipid compositional gradients reveals diffusion coefficients, phase separation parameters, and binding densities as a function of localized lipid mixture. Compositional gradients are formed by directed self assembly where rapid-prototyping techniques (i.e., additive manufacturing or laser-cutting) prescribe lipid geometries that self-spread, heal and mix by diffusion.

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