Faculty Research Interests
More complete information can be obtained by calling individual faculty or consulting the Research Opportunities book in the Department Office.
My laboratory focuses on chromatin remodeling factors, which utilize the energy of ATP to slide, remodel, or assemble nucleosomes. Understanding the normal function of these proteins is critical since their loss can lead to mis-regulation of the genome and several distinct forms of disease, including cancer.
Molecular modeling as a way of understanding the mechanism of chemical processes with a particular focus on thermally induced rearrangements of organic molecules.
- Cell and molecular biology
- Gene expression
- Pre-mRNA splicing in yeast
- Lethal ring-Y chromosomes
- Satellite divergence and hybrid incompatibility
- Effects of selfish B chromosomes
- Spiroplasma-induced male killing
Evolutionary genomics, Genomic basis of adaption, Population genomics, Molecular evolution
Students in my lab work on ecological questions involving coastal marine invertebrates. Past/current projects include:
- The preference of predatory snails for native and nonnative oysters in Newport Bay
- The effect of temperature on the metabolic rates of intertidal animals
- The effects of air and water temperature on the feeding rates of predatory snails
- Using sound to monitor the feeding behavior of predatory snails
- The growth and survival of intertidal barnacles under warm and cool temperatures
See research interests
Viral Vectors for Vaccine Development
- NMR studies of nucleoside dynamics
- FTIR studies of dynamics in methylated DNA
- High Resolution NMR of DNA Binding Sites
- Solid-state deuterium NMR of DNA
- Effects of cobalt complexes on genetic transformations
Interested students should contact Prof. Landsberg for a description of current thesis topics this semester.
**** See my faculty web-page for current opportunities *****
- Studies in evolution of islands, cave biology
- Late Quaternary paleontology of mammals; recent mammalian extinctions
- Island biogeographic analyses
- Late Quaternary climate and sea-level change.
- Cave science, including microclimate modelling.
- Biology of Fisheries Science
- Population/habitat management models for Southern California steelhead or Eastern Sierra brown trout (computer modeling)
- Development of antenna configurations for reading Passive Integrated Transponders in streams ( practical electronics)
- Use of bootstrap in Monte-Carlo techniques to establish confidence intervals on instream flow decision tools ( applies statistics and programming)
- Habitat modeling from closely-spaced transects in streams ( field measurements, hydraulic modeling)
- Economics and policy related to biology
- The economic consequences of listing Southern California steelhead as endangered
- A decision model for policies associated with listing Southern California Steelhead as endangered.
- Environmental Management
- Application of the ISO 14000 environmental management standard to a small manufacturer
Urban Air Pollution Chemistry of Fine Particulate Matter Health and Environmental Impacts of Nuclear Testing in Kazakhstan Environmental Policy
Broadly, I support research by science students interested in the Earth and Environmental Sciences (Soil Science and Geology), especially: soil genesis, mineral geochemistry, geomorphology/landscape evolution, and paleoenvironmental reconstruction. I work with thesis students who have completed at least one semester of introductory earth science (e.g., EA55L KS, GEOL 020 PO), have demonstrated an interest in the physical components of Environmental Systems, and/or who have taken another course in relevant topics with me (EA103, EA30L, etc.).
For a more detailed description of my research program please refer to https://schmitzlab.info
- Analysis of morphological evolution. Students are measuring morphological traits in museum collections (e.g., LA County Museum of Natural History) and analyze the data from a functional and phylogenetic perspective.
- Retina physiology and visualization. After the arrival of our new confocal laser scanning microscope we can analyze retina fine structure with traditional histology, stereology, and immunohistochemistry. In addition to lab work, students are involved in developing new visualization techniques of spatial distributions of cells across the retina.
- Behavioral tests of visual performance. In order to groundtruth optical models we are carrying out experiments to determine the actual abilities of our study organisms.
All projects have a strong computational component.
Zhaohua Irene Tang
- Cell signaling for the interplay between cell-division cycle and gene expression events such as pre-mRNA processing, mRNA export, as well as heterochromatic silencing in eukaryotes involving several protein kinases including Dsk1 and Kic1.
- Genomic studies on genes involved in the cellular sensitivity and resistance to platinum-based anticancer drugs
- Genomic studies on conserved response networks to phenol derivatives as environmental stress factors
Conservation biology (especially for plants and insects), causes and effects of biological invasions, and pollination ecology. Thesis students in my lab carry out projects on a wide range of topics, but some examples of ongoing opportunities include research on:
- Interactions between native annual plants and invasive grasses at the Bernard Field Station.
- Effects of invasive herbivores and climate change on rare plant populations and communities of the California Channel Islands.
- Changes in pollination biology of native plants resulting from habitat fragmentation and introduced bees.
- Modeling extinction risk of rare species.
Ethan Van Arnam
- Natural products chemistry and chemical ecology
- See lab website for more details
- Cellular localization of histone deacetylase enzymes through GFP-tagging;
- Engineering gene knockout constructs of chromatin modification enzymes, generation of knockout cell lines, and phenotype characterization of mutant cells;
- Identification of protein complexes that modify chromatin;
- Mechanistic roles for histone deacetylase enzymes in the control of gene expression and other cellular processes
- Transition metal complexes: nitrile hydration, proton exchange on complexed nitriles, restricted rotation involving coordinated amides.
- Environmental chemistry: heavy metal pollutants in urban areas